منابع مشابه
5 Brain metabolism and cerebral blood flow
Cerebral blood flow is influenced and regulated by a number of factors, including arterial blood pressure, intracranial pressure, venous outflow, blood viscosity, PaCO2 and PaO2, collateral flow, vasoreactivity and the status of cerebral autoregulation. The regulation of vascular resistance lies mainly in the arterioles and precapillary segments (Auer and Loew, 1983). It is important to note th...
متن کاملFunctional imaging of dolphin brain metabolism and blood flow.
This report documents the first use of magnetic resonance images (MRIs) of living dolphins to register functional brain scans, allowing for the exploration of potential mechanisms of unihemispheric sleep. Diazepam has been shown to induce unihemispheric slow waves (USW), therefore we used functional imaging of dolphins with and without diazepam to observe hemispheric differences in brain metabo...
متن کاملModelling Blood Flow and Metabolism in the Piglet Brain During Hypoxia-Ischaemia: Simulating Brain Energetics
We have developed a computational model to simulate hypoxia-ischaemia (HI) in the neonatal piglet brain. It has been extended from a previous model by adding the simulation of carotid artery occlusion and including pH changes in the cytoplasm. Here, simulations from the model are compared with near-infrared spectroscopy (NIRS) and phosphorus magnetic resonance spectroscopy (MRS) measurements fr...
متن کاملModelling Blood Flow and Metabolism in the Preclinical Neonatal Brain during and Following Hypoxic-Ischaemia
Hypoxia-ischaemia (HI) is a major cause of neonatal brain injury, often leading to long-term damage or death. In order to improve understanding and test new treatments, piglets are used as preclinical models for human neonates. We have extended an earlier computational model of piglet cerebral physiology for application to multimodal experimental data recorded during episodes of induced HI. The...
متن کاملNew insights into coupling and uncoupling of cerebral blood flow and metabolism in the brain
The brain has high metabolic and energy needs and requires continuous cerebral blood flow (CBF), which is facilitated by a tight coupling between neuronal activity, CBF, and metabolism. Upon neuronal activation, there is an increase in energy demand, which is then met by a hemodynamic response that increases CBF. Such regional CBF increase in response to neuronal activation is observed using ne...
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ژورنال
عنوان ژورنال: British Journal of Anaesthesia
سال: 1976
ISSN: 0007-0912
DOI: 10.1093/bja/48.6.615